Article

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

2021-04-24

Abstract excerpt

<h4>ABSTRACT</h4> c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression. Although MYC is overexpressed in both early and metastatic disease and associated with poor survival, its impact on prostate transcriptional reprogramming remains elusive. We demonstrate that MYC overexpression significantly diminishes the androgen receptor (AR) transcriptional program (the set of genes directly targ...

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Identifiers and source

Literature Corpus work: 85c0965b-41ec-5539-909b-663ce57dedc6
DOI: 10.1101/2021.04.23.441016

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