Article

KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival

2025-07-02

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with a 5-year survival rate of 13%. Despite recent molecular stratification of tumors into distinct classical and basal-like cell states, most tumors are heterogeneous contain of both subtypes. Therefore, therapeutic approaches targeting one subtype may not be suitable for PDAC therapy. Here, we integrated chromatin accessibility (ATAC-seq), ge...

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Literature Corpus work: bdae8a40-4b4e-5f8e-9079-2a77abd20d34
DOI: 10.1101/2025.06.30.662301

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