Article

MYC and RNA Polymerase II Binding Near Transcriptional End Sites Regulate the Expression of Functionally-Related Genes

2026-06-26

Abstract excerpt

MYC oncoprotein binding at promoters and enhancers influences RNA polymerase II (RNAPII)-driven gene expression. Numerous genes also bind MYC near their transcriptional end sites (TESs). This often allows direct promoter-TES contact via looping and further regulates total and “read-through” transcription that extends beyond standard termination sites. We aimed here to better clarify the rules governing TES-associa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a8bd6ec-1dab-5a66-8135-0a787f9a4cae
DOI: 10.64898/2026.06.22.733817

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MYC and RNA Polymerase II Binding Near Transcriptional End Sites Regulate the Expression of Functionally-Related GenesDOI 10.64898/2026.06.22.733817Read

MYC and AP-1 oncogenes synergistically bind enhancers to rewire transcriptionSemantic proximity Read

MYC enhancer invasion promotes prognostic cancer type-specific gene programs through an epigenetic switchSemantic proximity Read

Protein binding and methylation on looping chromatin accurately predict distal regulatory interactionsSemantic proximity Read

The nascent transcriptome delineates the regulatory landscape in human health and diseaseSemantic proximity Read

Dynamics and Topology of Human Transcribed <i>Cis</i> -regulatory ElementsSemantic proximity Read

Hi-TrAC reveals fractal nesting of super-enhancersSemantic proximity Read

Static and dynamic DNA loops form AP-1 bound activation hubs during macrophage developmentSemantic proximity Read

Transcriptome analyses of tumor-adjacent somatic tissues reveal genes co-expressed with transposable elementsSemantic proximity Read

Normal and cancer tissues are accurately characterised by intergenic transcription at RNA polymerase 2 binding sitesSemantic proximity Read

Global mapping of c-Myc binding sites and target gene networks in human B cellsSemantic proximity Read

Transposable elements impact the human regulatory landscape through cell type specific epigenomic associationsSemantic proximity Read

Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte DifferentiationSemantic proximity Read