Article

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox

2023-09-13

Abstract excerpt

Alternative splicing is an essential mechanism for diversifying proteins, in which mature RNA isoforms produce proteins with potentially distinct functions. Two major challenges in characterizing the cellular function of isoforms are the lack of experimental methods to specifically and efficiently modulate isoform expression and computational tools for complex experimental design. To address these gaps, we develop...

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Literature Corpus work: 219c6200-6303-5d3f-8450-f57e93b61b4b
DOI: 10.1101/2023.09.12.557474

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