Article

Rewriting endogenous human transcripts with <i>trans</i> -splicing

2024-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Splicing bridges the gap between static DNA sequence and the diverse and dynamic set of protein products that execute a gene’s biological functions. While exon skipping technologies enable influence over splice site selection, many desired perturbations to the transcriptome require replacement or addition of exogenous exons to target mRNAs: for example, to replace disease-causing exons, repair t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb50431d-8d18-558c-baf6-ff252d183b0b
DOI: 10.1101/2024.01.29.577779

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rewriting endogenous human transcripts with <i>trans</i> -splicingDOI 10.1101/2024.01.29.577779Read

Programmable multi-kilobase RNA editing using CRISPR-mediated trans-splicingSemantic proximity Read

Programmable RNA writing with trans-splicingSemantic proximity Read

Repair of CRISPR-guided RNA breaks enables site-specific RNA editing in human cellsSemantic proximity Read

Small nuclear RNAs enhance protein-free RNA-programmable base conversion on mammalian coding transcriptsSemantic proximity Read

“A CRISPR-dCas13 RNA-editing tool to study alternative splicing”Semantic proximity Read

Spligation enables programmable chimeric RNA generation in living cellsSemantic proximity Read

Targeted RNA editing by direct delivery of an adenosine deaminase-antisense oligo conjugateSemantic proximity Read

An integrated RNA and CRISPR/Cas toolkit for multiplexed synthetic circuits and endogenous gene regulation in human cellsSemantic proximity Read

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolboxSemantic proximity Read

Genetic therapies for RNA mis-splicing diseases.Semantic proximity Read

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expressionSemantic proximity Read

Robust RNA editing via recruitment of endogenous ADARs using circular guide RNAsSemantic proximity Read