Article

Oncogenic alterations in the p53 pathway abolish oscillatory competence

2021-02-10

Abstract excerpt

The tumor suppressor p53 displays concentration oscillations in response to DNA damage, a behavior that has been suggested to be essential to its anti-cancer function. Many genetic alterations in the p53 pathway have been shown to be oncogenic, whether by experiment or by clinical associations with various cancers. These oncogenic alterations include somatic mutations, copy number variations and inherited polymorp...

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Literature Corpus work: 8eb47513-85d4-5ec1-9f59-00ffc03520d4
DOI: 10.1101/2021.02.09.430245

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