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Article

Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial.

Wiley interdisciplinary reviews. Systems biology and medicine - 1 Jul 2016

Castagnino Nicoletta, Maffei Massimo, Tortolina Lorenzo, Zoppoli Gabriele, Piras Daniela, Nencioni Alessio, Moran Eva, Ballestrero Alberto, Patrone Franco, Parodi Silvio

Abstract excerpt

Current colorectal cancer (CRC) treatment guidelines are primarily based on clinical features, such as cancer stage and grade. However, outcomes may be improved using molecular treatment guidelines. Potentially useful biomarkers include driver mutations and somatically inherited alterations, signaling proteins (their expression levels and (post) translational modifications), mRNAs, micro-RNAs and long noncoding...

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Identifiers

PMID: 27240214
DOI: 10.1002/wsbm.1342
PMCID: PMC6680205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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