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A Novel Prognostic Metric Resolves the <i>MYCN</i> enigma <i>in Silico</i> and Points to a Biosynthetic Regulatory Shift Driven by <i>MYCN</i> Amplification in Neuroblastoma

2025-11-14

Abstract excerpt

Neuroblastoma (NB) is the most common extra-cranial solid tumour in children. Although MYCN amplification is typically indicative of a poor prognosis, the expression level of MYCN has a non-monotonic relationship with the clinical outcome. This paper proposes an explanation for this phenomenon, which is called the MYCN enigma in the literature. The p53/MYCN metric, which is a measure of the p53 protein level re...

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Literature Corpus work
b2cc7d26-271a-569b-a8a3-ac19c94e3318
DOI
10.1101/2025.11.13.688307
Open publication

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A Novel Prognostic Metric Resolves the <i>MYCN</i> enigma <i>in Silico</i> and Points to a Biosynthetic Regulatory Shift Driven by <i>MYCN</i> Amplification in NeuroblastomaDOI 10.1101/2025.11.13.688307
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