Article

Inverse and Proportional <i>trans</i> Modulation of Gene Expression in Human Aneuploidies

2023-09-22

Abstract excerpt

Genomic imbalance in aneuploidy is often detrimental to organisms. To gain insight into the molecular basis of aneuploidies in humans, we analyzed transcriptome data from several autosomal and sex chromosome aneuploidies. The results showed that in human aneuploid cells, genes located on unvaried chromosomes are inversely or proportionally trans -modulated, while a subset of genes on the varied chromosomes are co...

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Literature Corpus work: fc9fd69e-4359-549f-8f7c-1fe31308b04a
DOI: 10.1101/2023.09.21.558906

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