Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors

Abstract excerpt

Extracellular targeted protein degradation (eTPD) is an emerging modality to regulate protein levels without genomic interruption. Current strategies co-opt lysosome-targeting receptors (LTRs) that are ubiquitously present in most cells, offering a high success rate of eTPD across cell types and tissues. Opening up the binding complementarity requirement from LTRs to any overexpressed cell surface receptor offers...

Topics

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• Acrylamides
• Agammaglobulinaemia Tyrosine Kinase
• Fluorescent Dyes
• Half-Life
• Intracellular Space
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

534e0df9-7ed5-5c09-b5c8-8ca7bca4e7b8

DOI

10.1101/2024.09.18.613672