Article

Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A

2024-06-26

Abstract excerpt

<title>Abstract</title> <p>BioPROTACs are heterobifunctional proteins designed for targeted protein degradation (TPD). They are useful not only for probing protein functions but also offer a therapeutic avenue for modulating disease-related proteins. To extend the use of TPD beyond just protein attenuation, we introduce a synthetic framework for logic-gated, switchable TPD to achieve temporal control of protein c...

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Literature Corpus work: b369728b-73b6-5220-a113-70593a9e6968
DOI: 10.21203/rs.3.rs-4583684/v1

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