Targeting the Interplay of Proteins through PROTACs for the Management of Cancer and Associated Disorders

Abstract excerpt

Cancer remains a formidable global health challenge, necessitating innovative therapeutic strategies. Traditional small-molecule inhibitors often face limitations in selectively targeting disease associated proteins, leading to side effects and incomplete therapeutic responses. Proteolysis targeting chimeras (PROTACs) have emerged as a promising approach to address these challenges. Unlike traditional inhibitors,...

Topics

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• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

8bdb606e-ee11-5248-a2ae-0e45177c3e64

DOI

10.2174/0115733947304806240417092449