Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation

Abstract excerpt

<title>Abstract</title> <p>Targeted degradation of membrane proteins would afford an attractive and general strategy for treating various diseases that remain difficult with the current PROTAC methodology. We herein report a covalent nanobody-based PROTAC strategy, termed GlueTAC, for targeted membrane protein degradation with high specificity and efficiency. We first designed a MS-based screening platform for ra...

Topics

Open a Topic to create a Post that cites this publication.

• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

c7ead3e8-8b00-5097-b17e-7164a9346ca4

DOI

10.21203/rs.3.rs-306528/v1