Article

Computational modelling of natural cell-to-cell heterogeneity reveals key parameters that control the diversity of human pancreatic islet β-cell excitability in response to glucose

2026-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Insulin-producing β-cells demonstrate remarkable heterogeneity in their individual responsiveness to glucose, and that cellular heterogeneity contributes to coordinating islet activity and glucose homeostasis. Our current understanding of how variation in cell-intrinsic factors control cellular excitability and insulin secretion is informed by foundational experiments conducted on dispersed sing...

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Literature Corpus work: 2147ba4f-1a68-5200-92cf-4db44a550492
DOI: 10.64898/2026.02.27.708039

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