Article

Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypes

2019-02-20

Abstract excerpt

<h4>Summary</h4> Pancreatic islet cells regulate glucose homeostasis through insulin and glucagon secretion; dysfunction of these cells leads to severe diseases like diabetes. Prior single-cell transcriptome studies have shown heterogeneous gene expression in major islet cell-types; however it remains challenging to reconcile this transcriptomic heterogeneity with observed islet cell functional variation. Here we...

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Literature Corpus work: 56aa40b8-c0e6-5a02-bc3a-987ebcdd5fcf
DOI: 10.1101/555110

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