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Article

Gap-junction coupling and ATP-sensitive potassium channels in human β-cell clusters: Effects on emergent dynamics.

Physical review. E - 1 Sept 2017

Loppini A, Pedersen M G, Braun M, Filippi S

Abstract excerpt

The importance of gap-junction coupling between β cells in pancreatic islets is well established in mouse. Such ultrastructural connections synchronize cellular activity, confine biological heterogeneity, and enhance insulin pulsatility. Dysfunction of coupling has been associated with diabetes and altered β-cell function. However, the role of gap junctions between human β cells is still largely unexplored. By...

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PMID: 29346932
DOI: 10.1103/PhysRevE.96.032403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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