Article

Linking molecular pathways and islet cell dysfunction in human type 1 diabetes

2025-02-21

Abstract excerpt

<h4>Summary</h4> Type 1 diabetes (T1D) is characterized by the autoimmune destruction of most insulin-producing β-cells, along with dysregulated glucagon secretion from pancreatic α-cells. We conducted an integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of islet cells from T1D donors to investigate the mechanisms underlying their dysfunction. Surviv...

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Literature Corpus work: fb3b6eec-2f0b-5f12-a26b-496735a2ebcb
DOI: 10.1101/2025.02.20.639325

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