Article

Calcium-dependent transcriptional profiles of human pancreatic islet cells reveal functional diversity in islet subpopulations

2023-09-12

Abstract excerpt

<h4>Aims/hypothesis</h4> Pancreatic islets depend on cytosolic calcium to trigger the secretion of glucoregulatory hormones and regulate the transcription of genes important for the response to stimuli. To date, there has not been an attempt to profile calcium-regulated gene expression in all islet cell types. Our aim was to construct a large single-cell transcriptomic dataset from human islets exposed to conditi...

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Literature Corpus work: a8bcd42b-f283-5e23-89d8-aaae69322037
DOI: 10.1101/2023.09.08.556709

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