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Article

How Heterogeneity in Glucokinase and Gap-Junction Coupling Determines the Islet [Ca2+] Response.

Biophysical journal - 3 Dec 2019

Dwulet JaeAnn M, Ludin Nurin W F, Piscopio Robert A, Schleicher Wolfgang E, Moua Ong, Westacott Matthew J, Benninger Richard K P

Abstract excerpt

Understanding how cell subpopulations in a tissue impact overall system function is challenging. There is extensive heterogeneity among insulin-secreting β-cells within islets of Langerhans, including their insulin secretory response and gene expression profile, and this heterogeneity can be altered in diabetes. Several studies have identified variations in nutrient sensing between β-cells, including glucokinase...

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Identifiers

PMID: 31753287
DOI: 10.1016/j.bpj.2019.10.037
PMCID: PMC6895742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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