Article

Effects of the spi1a gene on Alzheimer's disease-related phenotypes in a zebrafish model

2025-10-08

Abstract excerpt

<title>Abstract</title> <p> Genome-wide sequence analysis has identified the <italic>SPI1</italic> gene as a genetic risk factor for Alzheimer's disease (AD). <italic>SPI1</italic> encodes the PU.1 protein, which plays a critical role in microglial development and immune responses, primarily studied in mouse models. However, no studies have yet reported the impact of the <italic>SPI1</italic> gene on AD-re...

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Literature Corpus work: 77f4af86-6135-586d-b662-16f5eeadac4f
DOI: 10.21203/rs.3.rs-6961277/v1

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