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Article

Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis.

Nature communications - 11 May 2024

Kim Byungwook, Dabin Luke Child, Tate Mason Douglas, Karahan Hande, Sharify Ahmad Daniel, Acri Dominic J, Al-Amin Md Mamun, Philtjens Stéphanie, Smith Daniel Curtis, Wijeratne H R Sagara, Park Jung Hyun, Jucker Mathias, Kim Jungsu

Abstract excerpt

SPI1 was recently reported as a genetic risk factor for Alzheimer's disease (AD) in large-scale genome-wide association studies. However, it is unknown whether SPI1 should be downregulated or increased to have therapeutic benefits. To investigate the effect of modulating SPI1 levels on AD pathogenesis, we performed extensive biochemical, histological, and transcriptomic analyses using both Spi1-knockdown and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38734693
DOI: 10.1038/s41467-024-48484-x
PMCID: PMC11088624

Genes

SPI1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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