Article

Down the Penrose stairs: How selection for fewer recombination hotspots maintains their existence

2022-09-28

Abstract excerpt

In many species, meiotic recombination events tend to occur in narrow intervals of the genome, known as hotspots. In humans and mice, double strand break (DSB) hotspot locations are determined by the DNA-binding specificity of the zinc finger array of the PRDM9 protein, which is rapidly evolving at residues in contact with DNA. Previous models explained this rapid evolution in terms of the need to restore PRDM9 bi...

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Literature Corpus work: 21431c16-e1c5-5615-b9f5-1d4dfccc0a30
DOI: 10.1101/2022.09.27.509707

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