Article

Co-evolution between PRDM9 and target sites and the Recombination Hotspot Paradox

2022-09-30

Abstract excerpt

Recombination often concentrates in small regions called recombination hotspots where recombination is much higher than the genome’s average. In many vertebrates, including humans, gene PRDM9 specifies which DNA motifs will be the target for breaks that initiate recombination ultimately determining the location of recombination hotspots. Because the sequence that breaks (allowing recombination) is converted into t...

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Literature Corpus work: e3f06899-2755-5be7-8861-c6121b9e93c6
DOI: 10.1101/2022.09.29.510084

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