Article
The Recombination Hotspot Paradox: Co-evolution between PRDM9 and its target sites.
Theoretical population biology - 1 Oct 2023
Úbeda Francisco, Fyon Frédéric, Bürger Reinhard
Abstract excerpt
Recombination often concentrates in small regions called recombination hotspots where recombination is much higher than the genome's average. In many vertebrates, including humans, gene PRDM9 specifies which DNA motifs will be the target for breaks that initiate recombination, ultimately determining the location of recombination hotspots. Because the sequence that breaks (allowing recombination) is converted into...
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