Article

Spatial ligand–receptor gene annotations carry conditional heritability association across human tissues

2026-03-31

Abstract excerpt

Methods that map genetic risk to cells do not directly test whether spatially organized ligand–receptor (LR) gene annotations carry conditional heritability association. Here we introduce EdgeMap, which scores each gene by the spatial activity of its LR contexts in spatial transcriptomics data, maps these scores alongside cell-intrinsic annotations to SNP-level LD scores, and tests both jointly against GWAS summar...

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Literature Corpus work: 2135a641-4f8c-5486-9611-9ddf90b6d64c
DOI: 10.64898/2026.03.29.715138

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