Article

PRISMA: A tensor-based framework for deconstructing the genetic architecture of complex diseases, with application to diabetic retinopathy

2026-05-28

Abstract excerpt

Complex-disease GWAS compress tissue-dependent genetic effects into aggregate locus-level statistics, obscuring regulatory trajectories that shape heterogeneous disease biology. We developed PRISMA (Poly-genic Risk Integration via Summary-statistics Multi-tissue Array-decomposition), an LD-aware summary-statistics framework that integrates GWAS and multi-tissue cis-eQTL evidence through graph Laplacian-regularized...

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Literature Corpus work: 4e6b96ac-9abf-50ec-8a53-3c4aabbdaa1f
DOI: 10.64898/2026.05.25.727382

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