Article

SMECT: a framework for benchmarking post-GWAS methods for spatial mapping of cells associated with human complex traits

2026-02-16

Abstract excerpt

Spatially resolving the cellular basis of complex human traits is essential for elucidating disease mechanisms, yet the comparative performance of computational methods for this task has not been systematically evaluated. Here, we present SMECT (Spatial Mapping Evaluation of Complex Traits), the first comprehensive framework for systematically evaluating methods that integrate genetic data with spatial transcripto...

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Literature Corpus work: 07d786af-e45e-5c3d-98d4-a690fb9fe38c
DOI: 10.64898/2026.02.14.705903

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