Article
Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues.
PLoS genetics - 1 Nov 2016
Wheeler Heather E, Shah Kaanan P, Brenner Jonathon, Garcia Tzintzuni, Aquino-Michaels Keston, Cox Nancy J, Nicolae Dan L, Im Hae Kyung
Abstract excerpt
Understanding the genetic architecture of gene expression traits is key to elucidating the underlying mechanisms of complex traits. Here, for the first time, we perform a systematic survey of the heritability and the distribution of effect sizes across all representative tissues in the human body. We find that local h2 can be relatively well characterized with 59% of expressed genes showing significant h2 (FDR <...
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