Article

Population-specific causal disease effect sizes in functionally important regions impacted by selection

2019-10-15

Abstract excerpt

Many diseases and complex traits exhibit population-specific causal effect sizes with trans-ethnic genetic correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We developed a new method, S-LDXR, for stratifying squared trans-ethnic genetic correlation across genomic annotations, and applied S-LDXR to genome-wide association summary statistics for 31 diseases and complex traits i...

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Literature Corpus work: 409a510b-37ad-55b5-9cc8-4028bfdcf276
DOI: 10.1101/803452

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