Article

Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits

2025-05-02

Abstract excerpt

Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease processes, we integrated 31 human and mouse spatial datasets from 8 organs with genes that are genetically implicated in 32 human diseases. Applying our novel approach STEAM, we identified both known and novel roles...

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Literature Corpus work: be01807e-dc78-5f7a-9a31-acde11bca23d
DOI: 10.1101/2025.05.02.651876

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