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Article

Population-specific causal disease effect sizes in functionally important regions impacted by selection.

Nature communications - 17 Feb 2021

Shi Huwenbo, Gazal Steven, Kanai Masahiro, Koch Evan M, Schoech Armin P, Siewert Katherine M, Kim Samuel S, Luo Yang, Amariuta Tiffany, Huang Hailiang, Okada Yukinori, Raychaudhuri Soumya, Sunyaev Shamil R, Price Alkes L

Abstract excerpt

Many diseases exhibit population-specific causal effect sizes with trans-ethnic genetic correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We develop a new method, S-LDXR, for stratifying squared trans-ethnic genetic correlation across genomic annotations, and apply S-LDXR to genome-wide summary statistics for 31 diseases and complex traits in East Asians (average N = 90K)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33597505
DOI: 10.1038/s41467-021-21286-1
PMCID: PMC7889654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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