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Multiomics analysis of homologous recombination deficiency across cancer types.

Biomolecules & biomedicine - 11 Dec 2024

Dong Lin, Li Lin, Zhu Linyan, Xu Fei, Zhang Rumeng, Li Qiushuang, Zhu Yong, Zeng Zhutian, Ding Keshuo

Abstract excerpt

There remains ongoing debate regarding the association of homologous recombination deficiency (HRD) with patient survival across various malignancies, highlighting the need for a comprehensive understanding of HRD's role in different cancer types. Based on data from databases, we conducted a multivariable omics analysis on HRD in 33 cancer types, focusing mainly on 23 cancers in which HRD was significantly...

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DNA Methylation
Gene Expression Regulation, Neoplastic
Genomics
Homologous Recombination
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

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PMID: 39073402
DOI: 10.17305/bb.2024.10448
PMCID: PMC11647252

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