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Article

Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.

The oncologist - 1 Sept 2021

Toh MingRen, Ngeow Joanne

Abstract excerpt

Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR genes are established cancer susceptibility genes with clinically actionable pathogenic variants (PVs). Classically, BRCA1 and BRCA2 germline PVs are associated with significant breast and ovarian cancer risks. Patients with BRCA1 or BRCA2 PVs display worse clinical outcomes but respond better to platinum-based chemotherapies and...

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Identifiers

PMID: 34021944
DOI: 10.1002/onco.13829
PMCID: PMC8417864

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