Article

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

2024-02-02

Abstract excerpt

Targeted protein degradation (TPD) has emerged as an effective strategy to eliminate disease-causing proteins by inducing their interactions with the protein degradation machinery. First-generation TPD agents exploit a limited set of broadly expressed E3 ubiquitin ligases with constitutive activity, forbidding their application to proteins requiring higher levels of targeting selectivity. Here, by phenotype-based...

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Literature Corpus work: f0407149-7a20-5636-b475-531b8c41b3b3
DOI: 10.1101/2024.01.31.578122

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