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Article

ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity

8 Jul 2017

Abstract excerpt

High temperature requirement A1 (HtrA1) belongs to an ancient protein family that is linked to various human disorders. The precise role of exon 1-encoded N-terminal domains and how these influence the biological functions of human HtrA1 remain elusive. In this study, we traced the evolutionary origins of these N-terminal domains to a single gene fusion event in the most recent common ancestor of vertebrates. We...

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PMID: 28992183
DOI: 10.1093/jmcb/mjx024

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