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Article

CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD.

Proceedings of the National Academy of Sciences of the United States of America - 9 May 2023

Chang Ya-Ju, Jenny Laura A, Li Yong-Shi, Cui Xuan, Kong Yang, Li Yao, Sparrow Janet R, Tsang Stephen H

Abstract excerpt

Genome-wide association studies (GWAS) have identified genetic risk loci for age-related macular degeneration (AMD) on the chromosome 10q26 (Chr10) locus and are tightly linked: the A69S (G>T) rs10490924 single-nucleotide variant (SNV) and the AATAA-rich insertion-deletion (indel, del443/ins54), which are found in the age-related maculopathy susceptibility 2 (ARMS2) gene, and the G512A (G>A) rs11200638 SNV, which...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Clustered Regularly Interspaced Short Palindromic Repeats
Share to Complement Factor H
Share to High-Temperature Requirement A Serine Peptidase 1
Share to Induced Pluripotent Stem Cells
Share to Macular Degeneration
Share to Oxidative Stress
Share to Proteins
Share to Serine Endopeptidases

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Identifiers

PMID: 37126685
DOI: 10.1073/pnas.2215005120
PMCID: PMC10175836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD.PMID 37126685Read ↗

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