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Article

Human RNA polymerase III termination favors decomposition over facilitated recycling.

Nature communications - 23 May 2026

Han Sun, Wang Qianmin, Song Eunho, Kang Changwon, Xu Yanhui, Hohng Sungchul

Abstract excerpt

Eukaryotic transcription termination remains incompletely understood. Using single-molecule fluorescence assays, we examined intrinsic termination by human RNA polymerase III (RNAP3) and identified mechanistic trifurcation leading to readthrough and two termination pathways with distinctive dissociation kinetics. The dominant pathway, decomposing termination, involves (near-)simultaneous dissociation of RNA and...

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Identifiers

PMID: 42177175
DOI: 10.1038/s41467-026-73393-6
PMCID: PMC13385618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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