Article

The nascent transcriptome delineates the regulatory landscape in human health and disease

2025-09-26

Abstract excerpt

Transcriptional regulatory elements (TREs) orchestrate gene expression programs fundamental to cellular identity and transitions across physiological and pathological states. Here, we present a high-resolution atlas of RNA Polymerase II-engaged TREs (enhancers and promoters) across all major human organ systems and a broad spectrum of developmental and disease states. This atlas is generated using PRO-cap, a highl...

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Literature Corpus work: 42806df1-d9be-5c5e-b1db-2a0f4ef7b3b6
DOI: 10.1101/2025.09.24.676871

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