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Nonlinear dynamic genetic regulation identifies peripheral drivers of neurodegenerative disease progression

2026-01-30

Abstract excerpt

<h4>Summary</h4> The dynamic genetic regulation of gene expression during the progression of common neurodegenerative diseases (NDDs) remains poorly characterized, obscuring the genetic architecture of longitudinal clinical traits. Here, we present 2sGen-GPS, a two-stage genetic Granger temporal causality framework designed to integrate genetic variants, intermediate longitudinal molecular traits, and disease pro...

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Literature Corpus work
20d292de-2f9c-5eac-a5b0-b42e7c17236c
DOI
10.64898/2026.01.29.26345161
Open publication

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Nonlinear dynamic genetic regulation identifies peripheral drivers of neurodegenerative disease progressionDOI 10.64898/2026.01.29.26345161
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