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Genetic Architecture of Neurological Disorders and Their Endophenotypes: Insights from Genetic Association Studies.

Current topics in behavioral neurosciences - 1 Jan 2024

Sargurupremraj Muralidharan

Abstract excerpt

Population-scale genetic association studies of complex neurologic diseases have identified the underlying genetic architecture as multifactorial. Despite the study sample sizes reaching the millions, the identified disease-related genes explain only a small fraction of the phenotypic variance. Notable advancements in statistical methods now enable researchers to gain insights even from genomic regions where...

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PMID: 39138743
DOI: 10.1007/7854_2024_513

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