Article

Constructing Parkinson's disease progression- endotype molecular networks for drug repurposing: multi-omics evidence aggregation and large-scale real-world data validation

2024-01-30

Abstract excerpt

Parkinson's disease (PD) presents with considerable clinical heterogeneity, spanning motor and non-motor symptoms with variable progression trajectories. To investigate the molecular drivers of this variability and identify therapeutic opportunities, we conducted a multi-omics, network-based analysis of the Parkinson's Progression Markers Initiative (PPMI) cohort, with independent validation in the Parkinson's Dis...

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Literature Corpus work: 26c464f2-8b0c-585a-a7ed-d2f53d64a0ea
DOI: 10.1101/2024.01.29.24301961

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