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Article

Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens.

Human genomics - 31 Dec 2024

Cocoș Relu, Popescu Bogdan Ovidiu

Abstract excerpt

Neurodegenerative diseases present complex genetic architectures, reflecting a continuum from monogenic to oligogenic and polygenic models. Recent advances in multi-omics data, coupled with systems genetics, have significantly refined our understanding of how these data impact neurodegenerative disease mechanisms. To contextualize these genetic discoveries, we provide a comprehensive critical overview of genetic...

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Identifiers

PMID: 39736681
DOI: 10.1186/s40246-024-00704-7
PMCID: PMC11687004

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