Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.

doi:10.1038/s41588-021-00847-6

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Article

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.

Nature genetics - 1 Jun 2021

Liu Ganqiang, Peng Jiajie, Liao Zhixiang, Locascio Joseph J, Corvol Jean-Christophe, Zhu Frank, Dong Xianjun, Maple-Grødem Jodi, Campbell Meghan C, Elbaz Alexis, Lesage Suzanne, Brice Alexis, Mangone Graziella, Growdon John H, Hung Albert Y, Schwarzschild Michael A, Hayes Michael T, Wills Anne-Marie, Herrington Todd M, Ravina Bernard, Shoulson Ira, Taba Pille, Kõks Sulev, Beach Thomas G, Cormier-Dequaire Florence, Alves Guido, Tysnes Ole-Bjørn, Perlmutter Joel S, Heutink Peter, Amr Sami S, van Hilten Jacobus J, Kasten Meike, Mollenhauer Brit, Trenkwalder Claudia, Klein Christine, Barker Roger A, Williams-Gray Caroline H, Marinus Johan, Scherzer Clemens R

Abstract excerpt

A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the course that the disease takes over time (progression and prognosis). To assess how genetic variation influences the progression of PD over time to dementia, a major determinant for quality of life, we performed a longitudinal genome-wide survival study of 11.2 million variants in 3,821 patients with PD over 31,053 visits....

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PMID: 33958783
DOI: 10.1038/s41588-021-00847-6
PMCID: PMC8459648

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