Article

Parkinson’s Disease motor and non-motor progression models emerge from pathway-level transcriptomics

2026-02-27

Abstract excerpt

<h4>Background</h4> Prognosis and therapeutic management in Parkinson’s disease remain challenging due to the disease’s heterogeneous progression and symptom presentation and lack of reliable biomarkers to predict individual disease trajectories. <h4>Objective</h4> To determine whether baseline blood transcriptomes, analyzed through biologically defined pathway gene sets, contain signatures that distinguish dist...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f728e6cc-8539-5efa-9d4c-9b6623c60868
DOI: 10.64898/2026.02.25.26346261

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Parkinson’s Disease motor and non-motor progression models emerge from pathway-level transcriptomicsDOI 10.64898/2026.02.25.26346261Read

Transcriptomics profiling of Parkinson’s disease progression subtypes reveals distinctive patterns of gene expressionSemantic proximity Read

Transcriptomics profiling of Parkinson’s disease progression subtypes reveals distinctive patterns of gene expressionSemantic proximity Read

Identification of Parkinson PACE subtypes and repurposing treatments through integrative analyses of multimodal clinical progression, neuroimaging, genetic, and transcriptomic dataSemantic proximity Read

Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal dataSemantic proximity Read

Leveraging blood RNA expression to understand Parkinson’s disease heterogeneity and progressionSemantic proximity Read

Constructing Parkinson's disease progression- endotype molecular networks for drug repurposing: multi-omics evidence aggregation and large-scale real-world data validationSemantic proximity Read

Genetically-Informed Prediction of Short-Term Parkinson’s Disease ProgressionSemantic proximity Read

Plasma Proteomics for Parkinson’s Disease: Diagnostic Classification, Severity Association, and Therapeutic HypothesesSemantic proximity Read

Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson diseaseSemantic proximity Read

The Quest for a Universal Parkinson’s Transcriptomics Signature is Derailed by Inherent Variability between PatientsSemantic proximity Read

Machine Learning Prediction of Parkinson’s Disease Onset and Subtype Using Germline VariantsSemantic proximity Read

Integrated Analysis of Single-Cell RNA Sequencing and Transcriptome Data Identifies a Pyroptosis-Associated Diagnostic Model for Parkinson’s DiseaseSemantic proximity Read