Article

Nuclear-injuries by aberrant dynein-forces defeat proteostatic purposes of Lewy Body Inclusions

2021-10-30

Abstract excerpt

Biogenesis of inclusion bodies (IBs) facilitates protein quality control (PQC). Canonical aggresomes execute degradation of misfolded proteins while non-degradable amyloids quarantine into Insoluble Protein Deposits. Lewy Bodies (LBs) are well-known neurodegenerative IBs of α-Synuclein associated diseases like Dementia with Lewy bodies (DLB) and Parkinson’s disease. Intriguingly, the PQC benefits and drawbacks ass...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c8bfd03-c1e9-59e0-8e67-a6fd6670f233
DOI: 10.1101/2021.10.29.466393

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nuclear-injuries by aberrant dynein-forces defeat proteostatic purposes of Lewy Body InclusionsDOI 10.1101/2021.10.29.466393Read

The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is the major driver of neurodegeneration in synucleinopathiesSemantic proximity Read

Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementiaSemantic proximity Read

All Roads Lead to Rome: Different Molecular Players Converge to Common Toxic Pathways in NeurodegenerationSemantic proximity Read

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodiesSemantic proximity Read

Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed <i>C. elegans</i> Neurons and Influence Large Vesicle Extrusions as ExophersSemantic proximity Read

Pathological α-Synuclein Perturbs Nuclear IntegritySemantic proximity Read

Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s DiseaseSemantic proximity Read

Neurodegeneration and the ordered assembly of α-synucleinSemantic proximity Read

Regulation of physiological and pathological condensates by molecular chaperonesSemantic proximity Read

Nup62 is recruited to pathological condensates and promotes TDP-43 insolubility in C9orf72 and sporadic ALS/FTLD.Semantic proximity Read

UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.Semantic proximity Read

Nucleo–cytoplasmic transport defects and protein aggregates in neurodegenerationSemantic proximity Read