Article

Tweek-dependent formation of ER-PM contact sites enables astrocyte phagocytic function and remodeling of neurons

2023-11-07

Abstract excerpt

<h4>Summary</h4> Neuronal remodeling generates an enormous amount of cellular debris, which is cleared from the nervous system by glia. At the larva-to-adult transition, Drosophila astrocytes transform into phagocytes and engulf degenerating larval synapses, axonal and dendritic debris. Here we show Tweek, a member of the bridge-like lipid transfer protein family, is upregulated in astrocytes as they ramp up the...

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Literature Corpus work: ad16e821-85f3-53ce-8921-c79b42631ae4
DOI: 10.1101/2023.11.06.565932

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