Article

Targeting the deNEDDylating enzyme NEDP1 to ameliorate ALS phenotypes through Stress Granules dissolution

2023-01-06

Abstract excerpt

<h4>Summary</h4> In Amyotrophic Lateral Sclerosis (ALS) motor neuron disease, mutations in proteins that upon stress localize within cytoplasmic protein inclusions called Stress Granules (SGs), are linked to the formation of aberrant inclusions, which are related to neuronal cell death. By combining studies in human cells and C. elegans including the use of Nanobodies, we found that inhibition of NEDP1, the enzy...

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Literature Corpus work: f27a1598-446a-5f58-ad1f-5e28a80b2053
DOI: 10.1101/2023.01.06.522988

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