Article

Gene Expression Modulation by the Linker of Nucleoskeleton and Cytoskeleton Complex Contributes to Proteostasis

2019-02-27

Abstract excerpt

<h4>Summary</h4> Cellular mechanisms that act in concert to maintain protein homeostasis (proteostasis) are vital for survival. Nevertheless, subsets of aggregation-prone proteins form toxic aggregates (proteotoxicity) that sometimes underlie the development of neurodegenerative diseases. Proteotoxic aggregates are often deposited in the vicinity of the nucleus, a process that is cytoskeleton-dependent. According...

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Literature Corpus work: 11fd8999-6013-5764-bc56-1449cd89f9b8
DOI: 10.1101/548859

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