Article

TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWAL

2014-07-01

Abstract excerpt

BACKGROUND: Malignant cells must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance mechanism not involving telomerase (alt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20ae5ab6-fa77-5b55-b37f-470d8afecc26
DOI: 10.1093/neuonc/nou206.18

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWALDOI 10.1093/neuonc/nou206.18Read

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.Semantic proximity Read

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.Semantic proximity Read

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.Semantic proximity Read

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss.Semantic proximity Read

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.Semantic proximity Read

The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas.Semantic proximity Read

Telomerase Reverse Transcriptase Promoter Mutations in A Cohort Of Adult Gliomas - Clinicopathological Correlates.Semantic proximity Read

When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.Semantic proximity Read

TERT, a promoter of CNS malignanciesSemantic proximity Read

Correlation between IDH, ATRX, and TERT promoter mutations in glioma.Semantic proximity Read

Paradoxical prognostic impact of TERT promoter mutations in gliomas depends on different histological and genetic backgrounds.Semantic proximity Read

New Molecular Considerations for Glioma: IDH, ATRX, BRAF, TERT, H3 K27M.Semantic proximity Read