Article
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
Nature communications - 25 May 2018
Diplas Bill H, He Xujun, Brosnan-Cashman Jacqueline A, Liu Heng, Chen Lee H, Wang Zhaohui, Moure Casey J, Killela Patrick J, Loriaux Daniel B, Lipp Eric S, Greer Paula K, Yang Rui, Rizzo Anthony J, Rodriguez Fausto J, Friedman Allan H, Friedman Henry S, Wang Sizhen, He Yiping, McLendon Roger E, Bigner Darell D, Jiao Yuchen, Waitkus Matthew S, Meeker Alan K, Yan Hai
Abstract excerpt
The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These molecular subgroups utilize distinct genetic mechanisms of telomere maintenance, either TERTp mutation leading to telomerase activation or ATRX-mutation leading to an alternative lengthening of telomeres phenotype (ALT). However, about 20% of...
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